The Latest
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Kendall Davis/BioPharma Dive
Tracker10 clinical trials to watch in the first half of 2026
After a lengthy downturn, the biotech industry finally gathered momentum in 2025. Key readouts in obesity, infectious disease and many rare conditions could help it continue.
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News roundupEarnings roundup: Amgen vs. FDA, Pfizer’s defense and Merck’s $70B-in-sales plan
Amgen is refusing U.S. regulators’ request to withdraw an inflammatory disease drug. Elsewhere, Pfizer battled skepticism on new obesity drug data, and Merck laid out its post-Keytruda future.
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Permission granted by Generate Biomedicines
IPO windowGenerate, an AI-driven Flagship startup, pitches an IPO
The biotech, which raised more than $800 million privately on the promise of artificial intelligence-aided drug discovery, is developing a potential competitor to the asthma treatment Tezspire.
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Adeline Kon/BioPharma Dive
Deep Dive // IPO windowBiotech IPOs are the industry’s lifeblood. Track how they’re performing.
Veradermics, Eikon Therapeutics, Agomab Therapeutics and SpyGlass Pharma collectively raised more than $1.2 billion in IPOs this week, and all either met or exceeded their offering targets.
Updated Feb. 4, 2026 -
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Obesity drugsLilly soars again as fast-selling weight loss drugs top Wall Street projections
Despite some angst over pricing pressure for GLP-1 drugs, Lilly’s bullish projections surpassed consensus estimates, while combined 2025 sales of Zepbound and Mounjaro eclipsed $36 billion.
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Novo shares tumble by double digits on grim sales outlook
In contrast to Lilly’s optimistic forecasts, Novo cited pricing constraints and competitive pressure in predicting up to a 13% decline in 2026 profits.
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Express Scripts reaches ‘landmark’ settlement with FTC in insulin suit
The agreement announced Wednesday includes sweeping changes to the Cigna PBM’s business practices, including no longer preferring expensive drugs over cheaper equivalents on standard formularies and reshoring its controversial rebate aggregator.
Updated Feb. 4, 2026 -
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Trump signs funding bill with PBM reforms, hospital-at-home and telehealth extensions
The funding package ends a partial government shutdown and enacts several healthcare policies, including preserving telehealth flexibilities in Medicare through 2027.
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Obesity drugsPfizer dips on new data for obesity drug acquired in $10B deal
A long-acting shot Pfizer got through a buyout of Metsera appeared “slightly inferior” to Lilly’s market-leading Zepbound in a Phase 2 trial, one analyst said.
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News roundupFDA launches ‘PreCheck’ program; AstraZeneca, Acadia drugs set back
The agency’s program will be open to pharmaceutical facilities that align with “national priorities.” Elsewhere, a self-administered lupus drug was turned back and MeiraGTx picked up another gene therapy.
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Gene editingGSK walks away from pioneering Wave RNA editing drug
Wave claimed GSK is handing back rights to the frontrunning program not because of questions about its potential, but because Wave is better suited to quickly advance a rare disease therapy.
Updated Feb. 2, 2026 -
Courtesy of Novo Nordisk
Obesity drugsNovo combination obesity shot meets goal in diabetes trial
CagriSema’s blood sugar and weight reductions exceeded the company’s blockbuster Wegovy, yet the drug might still struggle to rival Lilly's Zepbound.
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Courtesy of Sanofi
Sanofi drug, inherited from Genzyme, goes 1-for-2 in rare disease trials
The drug, which has suffered multiple setbacks over the years, could finally reach the market as a treatment for a form of Gaucher disease.
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Alamy
Amgen gives up on its once-prized eczema drug
The decision comes more than a year after disappointing initial Phase 3 results and casts further doubt on a class of autoimmune drugs thought to be challengers to treatments like Dupixent.
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Alamy
China competitionAstraZeneca leans into obesity, striking wide-ranging alliance with China’s CSPC
The deal, which involves up to eight “next-generation” weight loss medications and could be worth more than $18 billion, ranks as the largest licensing pact of its kind since the start of 2025, according to BioPharma Dive data.
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China competitionDrugs from China are reshaping biotech. Track the licensing deals here.
Roche’s deal with RNAi specialist SanegeneBio — which involves a $200 million upfront payment and $1.5 billion in future consideration — is its fourth licensing deal with a China-based drug developer since October.
Updated Feb. 3, 2026 -
Brian Tucker / BioPharma Dive/BioPharma Dive
The biopharma industry outlook on 2026: Optimism and tension
A spike in M&A activity and stock prices have pulled biotech out of a yearslong downturn. But regulatory tumult and fierce competition from China could short-circuit the sector's resurgence.
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News roundup
Moderna holds a ‘garage sale’; Roche defends obesity drug data
Moderna licensed out a rare disease drug for what an analyst called a “modest” sum. Elsewhere, Roche executives suggested better forthcoming obesity results and Summit’s PD-1/VEGF blocker got an FDA decision date.
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Q&APoliticization runs deeper than ever at FDA, risking long-term impacts
A massive overhaul of staffing and review processes have left the agency appearing heavily driven by the Trump administration’s political agenda, according to an economist and public policy expert.
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China competitionAstraZeneca strengthens China ties with planned $15B investment
AstraZeneca’s investment will “span the value chain” of drug research and development and comes amid a prolonged surge in dealmaking activity involving large pharmaceutical companies and their counterparts in China.
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Regenxbio gene therapy trials suspended by FDA over safety worries
The development of a brain tumor in a study participant led regulators to suspend a Hurler syndrome therapy in early testing and a treatment for Hunter syndrome nearing an FDA decision.
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Courtesy of Sanofi
Vaccines
Sanofi expects vaccine sales growth to dip amid ‘challenging environment’
On a conference call, executives cited “confusion” and declining vaccination rates in the U.S. while discussing a quarterly sales decline and anticipated slower growth in 2026.
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Emerging biotechTenpoint wins FDA nod for combination presbyopia eye drop
The biotech also raised $235 million in debt and equity funding to support marketing of the drop, which it claims to be an advance over existing treatments from AbbVie and others.
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Permission granted by Roche
Obesity drugsRoche, trailing in obesity, showcases new data for GLP-1 shot
A drug Roche acquired in a multibillion-dollar deal could be as effective as Zepbound, but may struggle to stand out in a crowded field, analysts said.
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Gene editingLilly bets on Seamless, delving further into genetic medicine for hearing loss
The potentially $1 billion alliance centered around a flexible gene editing technology adds to a portfolio of cutting-edge treatments the company is developing for hearing disorders.
