Clinical Trials: Page 3
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Courtesy of Novo Nordisk
Novo’s latest obesity pill spurs major weight loss in small trial
Early results from a Phase 1 study suggest the drug, amycretin, could be as potent as injectable medicines already sold by Novo and rival Eli Lilly.
By Jonathan Gardner • March 7, 2024 -
Alnylam, Roche blood pressure drug scores in second mid-stage trial
The study results further validate Roche’s recent decision to acquire rights to the drug, which is being developed for people with a stubborn form of hypertension.
By Jonathan Gardner • March 5, 2024 -
Explore the Trendline➔
Love Employee via Getty Images
TrendlineImmunology
Promising new mechanisms of action are driving significant pharmaceutical company investment into drugs for immune diseases like psoriasis and Crohn’s.
By BioPharma Dive staff -
Courtesy of Apogee Therapeutics
Apogee data hint at potential for long-lasting eczema drug
The biotech, which raised $300 million in an IPO last year, disclosed early results suggesting its therapy could be dosed less frequently than medicines from Eli Lilly and Regeneron.
By Kristin Jensen • March 5, 2024 -
klickit24 via Getty Images
Akero strengthens MASH drug’s case with new study data
The updated results show that responses to the drug, which is currently in late-stage testing, deepened with time, helping the company rebound from an earlier setback.
By Ben Fidler • March 4, 2024 -
Permission granted by QIAGEN
Sponsored by QIAGENUsing knowledge graphs to drive drug discovery
How are knowledge graphs changing the path of drug discovery?
March 4, 2024 -
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Incannex says psilocybin therapy lowered anxiety in small study
Shares of the Australian biotech rocketed up about 55% after the company announced results from a mid-stage study in generalized anxiety disorder.
By Jacob Bell • Feb. 28, 2024 -
Elizabeth Regan / Industry Dive
Viking data suggest obesity drug could rival Zepbound, Wegovy
The biotech’s drug led to significant weight loss in a Phase 2 trial, causing shares to double as analysts compared results to the marks set by drugs from Eli Lilly and Novo Nordisk.
By Jonathan Gardner • Feb. 27, 2024 -
koto_feja via Getty Images
Janux shares triple on early cancer immunotherapy data
Analysts viewed results for one of Janux’s drug, a T cell engager aimed at metastatic prostate cancer, as potentially best-in-class in a field that’s crowded with competitors.
By Ned Pagliarulo • Feb. 27, 2024 -
Courtesy of U.S. Food and Drug Administration
Minerva schizophrenia drug rejected by FDA
The agency’s complete response letter knocks back Minerva’s attempt to secure approval of the drug over agency reviewers’ objections.
By Ned Pagliarulo • Feb. 27, 2024 -
Warren Little via Getty Images
GSK drug meets goal in late-stage gonorrhea study
The drug, one of several GSK is developing for drug-resistant bacteria, has now succeeded in testing against two different infections.
By Delilah Alvarado • Feb. 26, 2024 -
Dr_Microbe via Getty Images
Obesity drugsObesity drug from Boehringer, Zealand succeeds in MASH trial
Zealand shares rose by more than one-third on the data, which provide further evidence so-called incretin drugs could help treat people with the liver disease.
By Ben Fidler • Feb. 26, 2024 -
Love Employee via Getty Images
NEJM paper fills in details on ‘remarkable’ CAR-T result in autoimmune disease
The full results spotlight cell therapy’s potential to treat lupus and other inflammatory conditions, but also the problems drugmakers must still solve.
By Ben Fidler • Feb. 21, 2024 -
Meletios Verras via Getty Images
Bavarian Nordic terminates cancer vaccine work
The Danish company scrapped a vaccine in Phase 1 testing and will exit oncology altogether, focusing instead on infectious disease research.
By Jonathan Gardner • Feb. 21, 2024 -
Lisa Maree Williams via Getty Images
AstraZeneca gets new Tagrisso OK as drug succeeds in another trial
The FDA approved the targeted therapy together with chemo for first-line metastatic lung cancer, while fresh trial results supported earlier use.
By Ned Pagliarulo • Feb. 20, 2024 -
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Sponsored by AllucentTranslating complex data into actionable insights, to create big value for smaller biotech companies
Why clinical pharmacology is critical to accelerating drug development, and how it can help drive value in a complex and rapidly evolving landscape.
Feb. 20, 2024 -
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ALS drug developmentALS drug from Denali, Sanofi falls short in mid-stage study
The disclosure the experimental therapy missed its trial goal comes after Sanofi had earmarked the drug for advancement into Phase 3.
By Delilah Alvarado • Feb. 16, 2024 -
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Alnylam changes to heart drug trial spark doubts, sinking shares
Analysts pressed Alnylam executives on the reasons for changes to HELIOS-B, a Phase 3 study in ATTR amyloidosis with cardiomyopathy that is important to the company’s future.
By Ben Fidler • Feb. 15, 2024 -
Elizabeth Regan / Industry Dive
Kalvista pill succeeds in late-stage study for rare swelling disorder
The biotech's drug quickly alleviated symptoms of the swelling attacks associated with hereditary angioedema, supporting the idea it could be an oral alternative to existing medicines.
By Ben Fidler • Updated Feb. 13, 2024 -
Ivan-Balvan via Getty Images
CSL heart drug misses goal in large study
The failure of CSL’s plasma-derived infusion, which contains a protein in “good” cholesterol, follows a similar path as pills from Lilly, Merck, Pfizer and Roche.
By Jonathan Gardner • Feb. 12, 2024 -
Stock via Getty Images
Takeda speeds narcolepsy drug to late-stage testing
New results have convinced Takeda to “rapidly” pursue a late-stage program for its drug TAK-861 in one type of narcolepsy, while in another the company opted not to continue.
By Jacob Bell • Feb. 9, 2024 -
Courtesy of Johnson & Johnson
J&J says top drug prospect works across autoimmune disorders
The pharma disclosed positive results from two studies testing its antibody drug nipocalimab in generalized myasthenia gravis or Sjögren's disease.
By Jacob Bell • Feb. 5, 2024 -
Permission granted by Vertex Pharmaceuticals
Non-opioid drug from Vertex cuts pain in major trial tests
While the overall results were positive, the drug fell short in both studies on a secondary goal comparing it to a widely prescribed opioid.
By Ned Pagliarulo • Jan. 30, 2024 -
Nemes Laszlo via Getty Images
State of PlayCAR-T for lupus: the ‘tip of the iceberg’ for cell therapy in autoimmune disease
Since a landmark paper in 2022, drugmakers have begun nearly a dozen trials of cell therapies for lupus, with more set to start. Here’s why their efforts are worth watching.
By Ben Fidler • Jan. 30, 2024 -
Permission granted by Bristol-Myers Squibb
Bristol Myers gets positive data in subcutaneous Opdivo trial
An under-the-skin Opdivo shot produced similar results to an intravenous formulation in kidney cancer, giving Bristol Myers a chance at sustaining sales past a key patent expiration in 2028.
By Jonathan Gardner • Jan. 29, 2024 -
Courtesy of Sarepta
Sarepta data show new Duchenne drug’s potency, but highlight side effects
A successor medicine to Sarepta's Exondys 51 appeared better at boosting dystrophin protein production, but was associated with electrolyte imbalances.
By Ned Pagliarulo • Jan. 29, 2024
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